Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC048
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2023-02-28 11:15
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.68 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.68 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 6, 'TP': 37, 'FP': 24}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 15, 'TN': 11, 'TP': 27, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 14, 'TN': 8, 'TP': 28, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.152
timePerCircleCoV 0.132307
timePerCircleSlope -0.0109166
meanError 2.01823
tremorFreq 7.32422
tremorRelPower 24.6577
tremorGyroAmpMean 0.0122842
tremorGyroAmpSlope 0.00385194
tremorGyroAmpCoV 0.381266
tremorCoordAmpMean 0.0440634
tremorCoordAmpSlope -0.00199909
tremorCoordAmpCoV 0.222814
tremorAccAmpMean 0.0236827
tremorAccAmpSlope 0.00396188
tremorAccAmpCoV 0.28105
tremorPcRelVar 0.618043
tremorPcX -0.839091
tremorPcY -0.543991

Circle Segment 1

Duration 5.6 s, Accuracy Estimate 1.509 (lower is better)

Circle Segment 2

Duration 4.48 s, Accuracy Estimate 2.363 (lower is better)

Circle Segment 3

Duration 6.24 s, Accuracy Estimate 1.482 (lower is better)

Circle Segment 4

Duration 4.52 s, Accuracy Estimate 1.978 (lower is better)

Circle Segment 5

Duration 6.08 s, Accuracy Estimate 1.84 (lower is better)

Circle Segment 6

Duration 4.92 s, Accuracy Estimate 1.851 (lower is better)

Circle Segment 7

Duration 4.6 s, Accuracy Estimate 2.328 (lower is better)

Circle Segment 8

Duration 4.96 s, Accuracy Estimate 1.721 (lower is better)

Circle Segment 9

Duration 5.64 s, Accuracy Estimate 1.974 (lower is better)

Circle Segment 10

Duration 4.48 s, Accuracy Estimate 3.135 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 12.344
timePerSpiralCoV 0.165345
timePerSpiralSlope -0.0389246
meanError 2.66124
tremorFreq 6.83594
tremorRelPower 31.2214
tremorGyroAmpMean 0.0200502
tremorGyroAmpSlope 0.00276685
tremorGyroAmpCoV 0.406699
tremorCoordAmpMean 0.0890874
tremorCoordAmpSlope 0.00456332
tremorCoordAmpCoV 0.836148
tremorAccAmpMean 0.0372748
tremorAccAmpSlope 0.00276532
tremorAccAmpCoV 0.30618
tremorPcRelVar 0.689844
tremorPcX -0.469557
tremorPcY 0.882902

Spiral Segment 1

Duration 17.68 s, Accuracy Estimate 2.579 (lower is better)

Spiral Segment 2

Duration 12.8 s, Accuracy Estimate 2.634 (lower is better)

Spiral Segment 3

Duration 13.04 s, Accuracy Estimate 2.681 (lower is better)

Spiral Segment 4

Duration 12.24 s, Accuracy Estimate 2.601 (lower is better)

Spiral Segment 5

Duration 11.08 s, Accuracy Estimate 2.757 (lower is better)

Spiral Segment 6

Duration 11.48 s, Accuracy Estimate 2.488 (lower is better)

Spiral Segment 7

Duration 11.32 s, Accuracy Estimate 2.403 (lower is better)

Spiral Segment 8

Duration 10.68 s, Accuracy Estimate 2.679 (lower is better)

Spiral Segment 9

Duration 12.24 s, Accuracy Estimate 2.926 (lower is better)

Spiral Segment 10

Duration 10.88 s, Accuracy Estimate 2.866 (lower is better)

Elel

eDurationMean 0.583194
eDurationStd 0.0861739
eDurationStdnorm 0.147762
eDurationMedian 0.56
eDurationQuartdelta 0.11
eDurationQuartdeltanorm 0.196429
eDurationKurt 3.07769
eDurationTrenddiff -0.0725
eDurationTrendratio 0.884
eWidthMean 4.92375
eWidthStd 1.27904
eWidthStdnorm 0.259769
eWidthMedian 4.563
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.333333
eWidthKurt 3.99118
eWidthTrenddiff -0.936
eWidthTrendratio 0.818182
eHeightMean 10.4097
eHeightStd 2.00037
eHeightStdnorm 0.192163
eHeightMedian 10.1205
eHeightQuartdelta 2.574
eHeightQuartdeltanorm 0.254335
eHeightKurt 2.19036
eHeightTrenddiff -2.574
eHeightTrendratio 0.774359
eAspectMean 0.477887
eAspectStd 0.103771
eAspectStdnorm 0.217146
eAspectMedian 0.46941
eAspectQuartdelta 0.152402
eAspectQuartdeltanorm 0.324667
eAspectKurt 2.66815
eAspectTrenddiff 0.0255238
eAspectTrendratio 1.0567
eSlantMean 0.0173199
eSlantStd 0.108267
eSlantStdnorm 6.25104
eSlantMedian 0.0295918
eSlantQuartdelta 0.152544
eSlantQuartdeltanorm 5.15494
eSlantKurt 2.30731
eSlantTrenddiff 0.036206
eRtopMean 0.757989
eRtopStd 0.0817159
eRtopStdnorm 0.107806
eRtopMedian 0.761141
eRtopQuartdelta 0.0937219
eRtopQuartdeltanorm 0.123133
eRtopKurt 3.7334
eRtopTrenddiff 0.0570137
eRbotMean 0.753358
eRbotStd 0.240696
eRbotStdnorm 0.319498
eRbotMedian 0.70786
eRbotQuartdelta 0.281526
eRbotQuartdeltanorm 0.397714
eRbotKurt 2.74492
eRbotTrenddiff -0.0117024
eRrightMean 0.865148
eRrightStd 0.0614416
eRrightStdnorm 0.0710186
eRrightMedian 0.865438
eRrightQuartdelta 0.105921
eRrightQuartdeltanorm 0.12239
eRrightKurt 1.71053
eRrightTrenddiff -0.00745214
eRleftMean 0.365915
eRleftStd 0.0851033
eRleftStdnorm 0.232576
eRleftMedian 0.363137
eRleftQuartdelta 0.11523
eRleftQuartdeltanorm 0.317318
eRleftKurt 3.48679
eRleftTrenddiff -0.0309953
lDurationMean 0.7325
lDurationStd 0.10455
lDurationStdnorm 0.142731
lDurationMedian 0.7275
lDurationQuartdelta 0.1
lDurationQuartdeltanorm 0.137457
lDurationKurt 4.64895
lDurationTrenddiff -0.0625
lDurationTrendratio 0.917219
lWidthMean 6.58125
lWidthStd 1.80319
lWidthStdnorm 0.273989
lWidthMedian 6.903
lWidthQuartdelta 2.34
lWidthQuartdeltanorm 0.338983
lWidthKurt 3.90287
lWidthTrenddiff -0.702
lWidthTrendratio 0.89916
lHeightMean 23.2157
lHeightStd 3.18846
lHeightStdnorm 0.137341
lHeightMedian 23.283
lHeightQuartdelta 3.627
lHeightQuartdeltanorm 0.155779
lHeightKurt 4.29894
lHeightTrenddiff -1.053
lHeightTrendratio 0.955556
lAspectMean 0.284526
lAspectStd 0.0714302
lAspectStdnorm 0.25105
lAspectMedian 0.277715
lAspectQuartdelta 0.0739787
lAspectQuartdeltanorm 0.266383
lAspectKurt 2.65832
lAspectTrenddiff -0.0044875
lAspectTrendratio 0.984011
lSlantMean 0.0632882
lSlantStd 0.0991685
lSlantStdnorm 1.56693
lSlantMedian 0.0546193
lSlantQuartdelta 0.145121
lSlantQuartdeltanorm 2.65696
lSlantKurt 4.2146
lSlantTrenddiff 0.0244774
lRtopMean 0.806842
lRtopStd 0.103022
lRtopStdnorm 0.127686
lRtopMedian 0.83156
lRtopQuartdelta 0.105796
lRtopQuartdeltanorm 0.127225
lRtopKurt 7.01455
lRtopTrenddiff -0.0114473
lRbotMean 0.635766
lRbotStd 0.307979
lRbotStdnorm 0.484423
lRbotMedian 0.60275
lRbotQuartdelta 0.347758
lRbotQuartdeltanorm 0.576953
lRbotKurt 5.92369
lRbotTrenddiff -0.0957271
lRrightMean 0.88562
lRrightStd 0.0871384
lRrightStdnorm 0.0983925
lRrightMedian 0.902808
lRrightQuartdelta 0.067579
lRrightQuartdeltanorm 0.0748543
lRrightKurt 14.5563
lRrightTrenddiff 0.00392919
lRleftMean 0.238373
lRleftStd 0.121892
lRleftStdnorm 0.511351
lRleftMedian 0.201527
lRleftQuartdelta 0.145626
lRleftQuartdeltanorm 0.722611
lRleftKurt 5.4938
lRleftTrenddiff -0.0562667

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.920014
sumTouchScores 20.2403
meanMovementTime 0.837143
numTouches 22
undershootPercentage 0
overshootPercentage 13.6364

FITTS Long Modified

meanTouchScore 0.946542
sumTouchScores 18.9308
meanMovementTime 0.954737
numTouches 20
undershootPercentage 0
overshootPercentage 10

ZigZag

numZigzags 7
timePerZigzagMean 15.8743
timePerZigzagCoV 0.183279
timePerZigzagSlope 0.0110691
meanError 3.30021
tremorFreq 6.15234
tremorRelPower 26.2298
tremorGyroAmpMean 0.017062
tremorGyroAmpSlope -0.00393707
tremorGyroAmpCoV 0.300937
tremorCoordAmpMean 0.241706
tremorCoordAmpSlope 0.00539673
tremorCoordAmpCoV 2.14999
tremorAccAmpMean 0.0805164
tremorAccAmpSlope -0.00106814
tremorAccAmpCoV 0.106164
tremorPcRelVar 0.506879
tremorPcX 0.470492
tremorPcY -0.882404

ZigZag Segment 1

Duration 16.44 s, Accuracy Estimate 2.565 (lower is better)

ZigZag Segment 2

Duration 16.44 s, Accuracy Estimate 2.687 (lower is better)

ZigZag Segment 3

Duration 15.36 s, Accuracy Estimate 1.883 (lower is better)

ZigZag Segment 4

Duration 14.8 s, Accuracy Estimate 2.871 (lower is better)

ZigZag Segment 5

Duration 10.68 s, Accuracy Estimate 8.596 (lower is better)

ZigZag Segment 6

Duration 20.4 s, Accuracy Estimate 2.361 (lower is better)

ZigZag Segment 7

Duration 17.0 s, Accuracy Estimate 2.138 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.216
timePerZigzagCoV 0.099087
timePerZigzagSlope -0.059322
zigzagHeightMean 65.5149
zigzagHeightCoV 0.0751889
zigzagHeightSlope 0.0304177
meanError 0.0397039
tremorFreq 6.83594
tremorRelPower 26.9262
tremorGyroAmpMean 0.0190777
tremorGyroAmpSlope 0.00185136
tremorGyroAmpCoV 0.320642
tremorCoordAmpMean 0.0701135
tremorCoordAmpSlope 0.00046389
tremorCoordAmpCoV 0.244066
tremorAccAmpMean 0.0386521
tremorAccAmpSlope -0.00162991
tremorAccAmpCoV 0.298049
tremorPcRelVar 0.691507
tremorPcX -0.146921
tremorPcY 0.989148

ZigZag Offset Segment 1

Duration 15.08 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 13.72 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 12.76 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 4

Duration 13.0 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 5

Duration 11.52 s, Accuracy Estimate 0.065 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.69}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.68}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.0016414722391675518}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.3026256016717179}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5902799076172822}